What is Peyronie’s disease?

Overview

Peyronie’s disease is a condition in which fibrous scar tissue forms in the deeper tissues under the skin of the penis. This causes curved, painful erections. It also can make the penis shorter while erect. Peyronie’s disease is not caused by cancer.

Penises vary in shape and size. So having a curved erection isn’t always a cause for concern. But Peyronie’s disease causes a serious bend or pain in some people.

This can prevent you from having sex. Or it might make it hard to get or keep an erection, which also is called erectile dysfunction. For many people, Peyronie’s disease also causes stress and anxiety.

Peyronie’s disease rarely goes away on its own. In most people with the condition, it will remain as is or may get slightly worse early on. Early treatment soon after you get the condition may keep it from getting worse or even improve symptoms. Even if you’ve had Peyronie’s disease for some time, treatment may help ease symptoms such as pain, curving and shortening.

Symptoms

Peyronie’s disease symptoms might start suddenly or appear over time. The most common symptoms include:

  • Scar tissue. The scar tissue linked with Peyronie’s disease also is called plaque. It can be felt under the skin of the penis as flat lumps or a band of hard tissue. The area over the scar tissue may feel tender.
  • A bend to the penis. The penis might curve upward or downward or bend to one side.
  • Erection problems. Peyronie’s disease might cause problems getting or keeping an erection. This also is called erectile dysfunction. Often though, people with Peyronie’s disease say they notice erectile dysfunction before the start of their other penile symptoms.
  • Shortening of the penis. The penis might become shorter during erections due to Peyronie’s disease.
  • Pain in the penis. This symptom might happen with or without an erection.
  • Other changes in how the penis looks. In some people with Peyronie’s disease, the erect penis might look narrow or indented. It might even take on an hourglass-like shape, with a tight, narrow band around the shaft.

The curving and penile shortening linked with Peyronie’s disease might become worse over time. Physical changes in the penis often get worse or stay the same during the first year to year and a half.

Pain during erections usually gets better within 1 to 2 years. The scar tissue, penile shortening and curving often remain. It’s not common, but the curving and pain of Peyronie’s disease can get better without treatment.

When to see a doctor

See a health care professional if you notice symptoms of Peyronie’s disease. Early treatment gives you the best chance to improve the condition or keep it from getting worse. If you’ve had the condition for some time, get a health care checkup if the pain, curving, length, or other changes bother you or your partner.

Causes

It’s thought Peyronie’s disease most often results from repeated injury to the penis during vigorous sex. But the penis also could be damaged during athletic activities or accidents. Many people with Peyronie’s disease can’t recall a specific injury that led to their symptoms.

During the healing process after injury to the penis, scar tissue forms. This can lead to a lump you can feel or to a curve in the penis.

Each side of the penis contains a spongelike tube called a corpus cavernosum. These tubes have many tiny blood vessels. Each of the corpora cavernosa is encased in a sheath of elastic tissue called the tunica albuginea. The sheath stretches during an erection.

When you become sexually aroused, more blood flows to these chambers. As the chambers fill with blood, the penis expands, straightens and stiffens into an erection.

In Peyronie’s disease, when the penis becomes erect, the area with the scar tissue doesn’t stretch. As a result, the penis bends or goes through other changes. This can be painful.

Risk factors

Minor injury to the penis doesn’t always lead to Peyronie’s disease. Various factors can contribute to poor wound healing and scar tissue buildup that might play a role in Peyronie’s disease. These include:

  • Family history. If a family member has Peyronie’s disease, you have a higher risk of the condition.
  • Connective tissue diseases. People who have certain conditions that affect connective tissue in the body seem to have a higher risk of getting Peyronie’s disease. For example, some people with Peyronie’s disease also have a thick cord under the skin of the palm that can pull the fingers inward. This is called Dupuytren contracture.
  • Age. Peyronie’s disease can happen at any age. But it becomes more common between the ages of 45 and 70. Curving of the penis in younger men less often is due to Peyronie’s disease. It is more commonly called congenital penile curvature. A small amount of curvature in younger men is typical and not concerning.

Other factors might be linked to Peyronie’s disease. These include certain health conditions, smoking and some types of prostate surgery.

Complications

Peyronie’s disease might lead to troubles that include:

  • Not being able to have sex.
  • Trouble getting or keeping an erection, also called erectile dysfunction.
  • Anxiety, stress, or depression over challenges having sex or the way your penis looks.
  • Stress on your relationship with your sexual partner.
  • Trouble having a child because it’s challenging or not possible to have sex.
  • Shorter penis length.
  • Penile pain.

Diagnosis

Health care professionals often can figure out if someone has Peyronie’s disease by doing a physical exam. They also might do tests to check for other conditions that can cause similar symptoms.

You might need the following tests:

  • Physical exam. Your health care professional feels your penis when it’s not erect to figure out the location and amount of scar tissue. The length of your penis also might be measured. If the condition becomes worse, this measurement helps determine whether the penis has gotten shorter. 

Your health care professional also might ask you to bring in photos of your erect penis taken at home. This can help determine the degree of curving, the location of scar tissue or other details that might guide treatment.

  • Other tests. Your health care professional might order an ultrasound or other tests to check your penis when it’s erect. Before testing, you’ll likely receive a shot directly into the penis that helps it become erect.

Ultrasound is the most commonly used test for penis conditions. It uses sound waves to make images of soft tissues inside the body. These tests can show the presence of scar tissue, blood flow to the penis and any other irregular signs.

Treatment

Treatment options for Peyronie’s disease depend on how long it’s been since you began having symptoms.

  • Acute phase. As scar tissue forms, changes in the curve or length of the penis become worse. You also may have pain during erections. The acute phase may last for 5 to 18 months.
  • Chronic phase. The scar tissue in the penis stops growing, and your symptoms become stable. You also have no penile pain or changes in the curve, length or other aspects of the penis. The chronic phase happens later in Peyronie’s disease.

Acute phase Peyronie disease treatment

For the acute phase of the condition, treatments include:

  • Traction therapy. When used early in the process, a device that holds the penis in a cradle and applies tension can be helpful. This is called penile traction therapy. It prevents length loss and limits curving.
  • Medicines. Some medicines taken by mouth or given in shots are options in this phase. Some medicines that have been used in the past clearly do not work. Others may or may not help. Your health care professional will likely talk with you in more detail.

Surgery is not recommended in the acute phase of Peyronie’s disease. It isn’t a treatment option until the condition stops becoming worse and any pain goes away. This lowers the chances of needing a second surgery.

Chronic phase Peyronie’s disease treatment

For the chronic phase of the disease, treatment choices include:

  • Watchful waiting, in which your health care team watches your condition closely and gives treatment if your symptoms become worse.
  • Injections or shots into the scar tissue.
  • Stretching devices, also called “traction” therapy.
  • Surgery to straighten the penis.

These treatments may be done alone or combined with one another.

Oral medications taken by mouth aren’t recommended in the chronic phase. They haven’t been shown to be effective at this stage of the disease.

Medications

Oral medicines have been tried to treat Peyronie’s disease. But research has shown that many don’t work consistently, and they are not as effective as other treatments.

In some people, medicines injected directly into the scar tissue on the penis might reduce curving and pain linked with Peyronie’s disease. Depending on the treatment, you might be given medicine that goes on the skin called a local anesthetic to prevent pain during the shots.

If you have one of these treatments, you’ll likely receive more than one shot over many months. Injection medicines also may be used along with oral medicines or traction therapy.

Medicines given by injection include:

  • Collagenase clostridium histolyticum (Xiaflex). This is the only FDA-approved medicine for Peyronie’s disease. It’s approved for use in adults with a moderate to severe curve and lumps under the skin that can be felt.

This treatment has been shown to improve curving and bothersome symptoms linked with Peyronie’s disease. The treatment works by breaking down the buildup of collagen protein in the scar tissue that causes the penis to curve. Collagenase seems to work better when it’s used along with traction therapy or another treatment called “modeling.” With modeling, a health care professional bends the penis in the opposite direction of the curve.

  • Verapamil. This medicine appears to work by disrupting the scar tissue and preventing further scar tissue from forming. It may help improve pain too. Verapamil also is used to treat high blood pressure.
  • Interferon. This medicine seems to disrupt fibrous tissue from being made. Interferon also seems to help break the fibrous tissue down. Interferon also has been shown to ease penile pain in people with Peyronie’s disease.

Ask your health care professional about the side effects of any medicine that you might take.

Surgery

Plication procedure of the penis to correct curvaturePlication of the penis 

Graft repair of the penis to correct curvature or other deformityGraft repair of the penis

Your doctor might suggest surgery if the curve or bend of your penis is severe, bothers you a lot or prevents you from having sex. Most often, surgery isn’t recommended until you’ve had Peyronie’s disease for 9 to 12 months. It’s also not recommended until the curve of your penis stops getting worse and stays the same for at least 3 to 6 months, and any pain goes away.

Common types of surgery for Peyronie’s disease include:

  • Suturing the unaffected side. Various procedures can be used to straighten the penis by restricting the longer side without scar tissue. These techniques are called suturing or plicating. They’re often used only for curves that are less severe.

Many plication techniques may be used. Most often, they have similar success rates. But the success of the surgery also depends on the surgeon’s experience and preference.

  • Incision or excision and grafting. With this type of surgery, the surgeon makes one or more cuts in the scar tissue. This lets the sheath stretch out and the penis straighten. The surgeon might remove some of the scar tissue.

A piece of tissue called a graft often is sewn into place to cover the holes in the tunica albuginea. The graft might be tissue from your own body, human or animal tissue.

Most often, this procedure is used to treat a serious curvature or other change, such as dents in the penis.

  • Penile implants. Surgery is done to place a device into the spongy tissue that fills with blood during an erection. You might receive implants that you can bend down most of the time and bend upward for sex. These are called semirigid implants.

More often, another type of implant is inflated with a pump implanted in the scrotum. Penile implants might be considered if you have both Peyronie’s disease and erectile dysfunction.

When the implants are put in place, the surgeon might do other procedures to improve the curve in the penis if needed.

The type of surgery used depends on your condition. Your health care team likely will take into account where in the penis your scar tissue is, how serious your symptoms are and other factors. If you are not circumcised, your health care professional might recommend a circumcision during surgery.

Your surgeon lets you know how long you should wait before you go back to work. Most often, you take a few days off. After surgery for Peyronie’s disease, you’ll need to wait 4 to 8 weeks before any sexual activity.

Before you get surgery for Peyronie’s disease, ask your surgeon about the risks. These may include:

  • Loss of feeling in the penis.
  • Erectile dysfunction.
  • More shortening of the penis.
  • Infection.
  • Rarely, the return of a curve in the penis after surgery.